Brain Health

ISB, along with a collaborative network of partners, is pioneering a multimodal approach that combines personal data, lifestyle factors, cognitive training and systems medicine — and is rigorously testing these new approaches in clinical trials. This approach is critical to prevent, slow, and even reverse many neurological conditions before they become irreversible.

A Systems Approach to Brain Health

“Brain health is the cornerstone of personal wellness, especially as we age. We need to monitor, preserve and improve the health of our most important organ throughout life.”

-Dr. Nathan Price, ISB professor


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Every single clinical trial created to test Alzheimer’s disease drugs have failed.

Many neurological conditions are difficult, if not impossible, to cure. This is especially true in the late stages of disease.

Alzheimer’s disease is one such debilitating condition that currently has no cure, and has stymied researchers at every turn.

Prevention and early detection are crucial to identify these conditions at the earliest possible stage.


To date, our researchers:

  • Use deep phenotyping  to create personal, dense, dynamic data (PD3) clouds in the hopes of identifying neurological conditions even before symptoms appear.
  • Are collaborating in clinical trials exploring the effects of health coaching and brain training exercises on cognitive function for patients with early-stage Alzheimer’s disease.
  • Developed partnerships to improve brain plasticity through cognitive training.
  • Secured grant funding from several institutions, including multiple grants from the National Institutes of Health, to enable a systems approach to tackling neurological conditions and identifying treatment possibilities.
  • Collaborated with a team that showed potential infectious agent-connection with Alzheimer’s disease.
  • Identify disease-perturbed networks through systems analysis of neurodegenerative diseases such as Alzheimer’s disease and Huntington’s disease.
The greatest hope for reversing and preventing Alzheimer’s disease and other neurological disorders is a multimodal approach that combines diet, exercise, drug treatment, coaching, brain training and other personalized treatments. This approach is championed by Dr. Mary Kay Ross, founder of the Seattle-based Brain Health & Research Institute.

Observational studies suggest this novel approach can slow, stop, and in some cases reverse Alzheimer’s disease progression. ISB is collaborating on research with BHRI to expand our understanding of the causes, effects and treatment of significant impairment of the human brain.

ISB is working to improve the standard of care for Alzheimer’s patients.

multimodal approach



ISB is leading analytics associated with a large consortia for Alzheimer’s disease, such as the Accelerating Medicines Partnership for Alzheimer’s Disease (AMP-AD), an effort funded by both the National Institutes of Health and a precompetitive consortium of pharmaceutical companies devoted to immediate global and free data sharing to advance the research community.  These efforts provide novel drug targets for developing network-informed approaches to Alzheimer’s treatments.


ISB and  several collaborators conducted Coaching for Cognition in Alzheimer’s (COCOA), a clinical trial testing how health coaching affects the cognitive function of patients with early-stage Alzheimer’s disease and analyzed longitudinal, multi-omic data to explore transitions in cognitive function over time.


  • Earls, John C., Noa Rappaport, Laura Heath, Tomasz Wilmanski, Andrew T. Magis, Nicholas J. Schork, Gilbert S. Omenn, Jennifer Lovejoy, Leroy Hood, and Nathan D. Price. 2019. “Multi-Omic Biological Age Estimation and Its Correlation With Wellness and Disease Phenotypes: A Longitudinal Study of 3,558 Individuals.” The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 74 (Supplement_1): S52–60.
  • Chakrabarty P, Li A, Ladd TB, Strickland MR, Koller EJ, Burgess JD, Funk CC, Cruz PE, Allen M, Yaroshenko M, Wang X, Younkin C, Reddy J, Lohrer B, Mehrke L, Moore BD, Liu X, Ceballos-Diaz C, Rosario AM, Medway C, Janus C, Li HD, Dickson DW, Giasson BI, Price ND, Younkin SG, Ertekin-Taner N, Golde TE. 2018. “TLR5 decoy receptor as a novel anti-amyloid therapeutic for Alzheimer’s disease.” Journal of Experimental Medicine.
  • Readhead B, Haure-Mirande JV, Funk CC, Richards MA, Shannon P, Haroutunian V, Sano M, Liang WS, Beckmann ND, Price ND, Reiman EM, Schadt EE, Ehrlich ME, Gandy S, Dudley JT. 2018. “Multiscale Analysis of Independent Alzheimer’s Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks of Human Herpesvirus.” Neuron.
  • Ament SA, Pearl JR, Cantle JP, Bragg RM, Skene PJ, Coffey SR, Bergey DE, Wheeler VC, MacDonald ME, Baliga NS, Rosinski J, Hood LE, Carroll JB, Price ND. 2018. “Transcriptional regulatory networks underlying gene expression changes in Huntington’s disease.” Molecular Systems Biology.
  • Price, Nathan D., Andrew T. Magis, John C. Earls, Gustavo Glusman, Roie Levy, Christopher Lausted, Daniel T. McDonald, et al. 2017. “A Wellness Study of 108 Individuals Using Personal, Dense, Dynamic Data Clouds.” Nature Biotechnology.
  • Ament SA, Pearl JR, Grindeland A, St Claire J, Earls JC, Kovalenko M, Gillis T, Mysore J, Gusella JF, Lee JM, Kwak S, Howland D, Lee MY, Baxter D, Scherler K, Wang K, Geman D, Carroll JB, MacDonald ME, Carlson G, Wheeler VC, Price ND, Hood LE. 2017. “High resolution time-course mapping of early transcriptomatic, molecular and cellular phenotypes in Huntington’s disease CAG knock-in mice across multiple genetic backgrounds.” Human Microbial Genetics.



We need your help to realize the full potential of multimodal therapy to slow, stop or reverse Alzheimer’s disease. A donation from you will help ensure that this critical research becomes a cornerstone of our brain health platform with the goal of positively impacting the standard of care for Alzheimer’s patients.

For more information, please contact:

Renee Duprel | 206.732.1287 |